Required for Reconstruction: This product is provided in a lyophilized (freeze-dried) state. For proper use and to maintain stability, Bacteriostatic Water is required for reconstitution.
Fox 04 10mg
FOXO4-DRI (also known as Proxofim) is a synthetic senolytic peptide designed to selectively eliminate senescent “zombie” cells. It works by disrupting the interaction between FOXO4 and the p53 protein, which triggers apoptosis (programmed cell death) in damaged cells while leaving healthy cells unharmed. Research Applications Senescence: Investigated for its ability to clear senescent fibroblasts and chondrocytes in aging/degeneration research. Potential in Models: Studied in animal models for its capacity to reduce biological age, improve tissue function, and alleviate age-related testosterone insufficiency
$200.00
10 in stock
COMES IN LYOPHILIZED POWDER FORM, BACTERIOSTATIC WATER NEEDED TO RECONSTITUTE
FOX 04-DRI is an investigational synthetic peptide studied for its senolytic properties. It selectively targets and eliminates “zombie” (senescent) cells —damaged cells that accumulate over time and trigger systemic inflammation—while leaving healthy tissue unharmed.
Documented Research Benefits (Animal Models)
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- Cellular Rejuvenation: Disrupts the \(FOXO4-p53\) protein interaction, prompting old, dysfunctional cells to undergo apoptosis (programmed cell death).
- Cardiovascular Health: Suppresses aortic aging, reduces vascular inflammation, and enhances endothelial function.
- Natural Hormone Regulation: Alleviates age-related testosterone secretion insufficiency by eliminating senescent Leydig cells, allowing the body to reactivate its natural function.
- Reduced Physical Decline: May combat age-related frailty, stiffness, and diminished endurance by improving overall tissue homeostasis.
Important Research Caveats
- Investigational Status: The peptide is exclusively for laboratory and preclinical research. It is not FDA-approved for human consumption.
- Risk Profile: Experimenting with this peptide carries significant risks, including potential harm to non-senescent cells, acute inflammation, and unquantified long-term cancer risks.
Chemical Profile & Structure
- Molecular Formula: \(C_{228}H_{388}N_{86}O_{64}\)
- Molecular Weight: ~5358 g/mol
- Structure Class: Synthetic peptide (D-retro-inverso configuration)
- Sequence: D-(Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly)
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